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Bi(OTf)3-Catalyzed Three-Component Synthesis of Amidomethylarenes and -Heteroarenes

Angelika E. Schneider, Georg Manolikakes*

*Department of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438 Frankfurt am Main, Germany, Email:

A. E. Schneider, G. Manolikakes, Synlett, 2013, 24, 2057-2060.

DOI: 10.1055/s-0033-1339654


A highly efficient Bi(OTf)3-catalyzed multicomponent synthesis of amidomethylated arenes and heteroarenes from readily available starting materials proceeds under mild conditions and has a broad substrate scope with water as the only side product.

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Key Words

multicomponent reactions, bismuth, acylimines, amidoalkylation, amidation, arylation

ID: J60-Y2013