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Design, Preparation, and Implementation of an Imidazole-Based Chiral Biaryl P,N-Ligand for Asymmetric Catalysis

Flavio S. P. Cardoso, Khalil A. Abboud and Aaron Aponick*

*Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, Florida 32611, United States, Email: aponickchem.ufl.edu

F. S. P. Cardoso, K. Abboud, A. Aponick, J. Am. Chem. Soc., 2013, 135, 14548-14551.

DOI: 10.1021/ja407689a


Abstract

π-Stacking can be used to increase the barrier to rotation in chiral atropisomers. Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a single enantiomer. This ligand performs exceptionally well in the enantioselective A3-coupling.

see article for more examples



Enantioselective Alkyne Conjugate Addition Enabled by Readily Tuned Atropisomeric P,N-Ligands

S. Mishra, J. Liu, A. Aponick, J. Am. Chem. Soc., 2017, 139, 3352-3355.


Key Words

Propargylamines, Multicomponent Reactions


ID: J48-Y2013