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Copper-Catalyzed Methyl Esterification Reactions via C-C Bond Cleavage

Yan Zhu, Hong Yan, Linhua Lu, Defu Liu, Guangwei Rong and Jincheng Mao*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China, Email:

Y. Zhu, H. Yan, L. Lu, D. Liu, G. Rong, J. Mao, J. Org. Chem., 2013, 78, 9898-9905.

DOI: 10.1021/jo4016387


A highly effective synthesis of methyl esters from benzylic alcohols, aldehydes, or acids via copper-catalyzed C-C cleavage from tert-butyl hydroperoxide is easily accessible and practical and offers an alternative to the traditional way.

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Key Words

TBHP, oxidation (alcohols, aldehydes), esters, methyl esters

ID: J42-Y2013