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Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

Valentín Hornillos, Massimo Giannerini, Carlos Vila, Martín Fañanás-Mastral* and Ben L. Feringa*

*Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands, Email:,

V. Hornillos, M. Giannerini, C. Vila, M. Fañanás-Mastral, B. L. Feringa, Org. Lett., 2013, 15, 5114-5117.

DOI: 10.1021/ol402408v


A palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds in the presence of Pd-PEPPSI-IPent or Pd2(dba)3/XPhos as the catalyst enables the preparation of biaryl and heterobiaryl compounds in high yields under mild conditions with short reaction times.

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ID: J54-Y2013