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Cobalt-Catalyzed Hydrofluorination of Unactivated Olefins: A Radical Approach of Fluorine Transfer

Hiroki Shigehisa*, Eriko Nishi, Mayu Fujisawa and Kou Hiroya

*Faculty of Pharmacy, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan, Email:

H. Shigehisa, E. Nishi, M. Fujisawa, K. Hiroya, Org. Lett., 2013, 15, 5158-5161.

DOI: 10.1021/ol402696h


An attractive catalytic hydrofluorination of olefins using a cobalt catalyst offers exclusive Markovnikov selectivity, functional group tolerance, and scalability. A preliminary mechanistic experiment showed the involvement of a radical intermediate.

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Key Words

fluoroalkanes, silanes

ID: J54-Y2013