Simple Synthesis of Sulfonyl Chlorides from Thiol Precursors and Derivatives by NaClO2-Mediated Oxidative Chlorosulfonation
Zhanhui Yang, Yongpeng Zheng, Jiaxi Xu*
*State Key Laboratory of Chemical Resource Engineering,
Department of Organic Chemistry, Faculty of Science, Beijing University of
Chemical Technology, Beijing 100029, P. R. of China,
Email: jxxumail.buct.edu.cn
Z. Yang, Y. Zheng, J. Xu, Synlett, 2013, 24, 2165-2169.
DOI: 10.1055/s-0033-1339675
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Abstract
A simple NaClO2-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts enables a convenient, safe, and environmentally benign synthesis of diverse sulfonyl chlorides in high yields. The procedure is also applicable to other substrates such as thiols, disulfides, thioacetates, and xanthates.
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Z. Yang, B. Zhou, J. Xu, Synthesis, 2014, 46, 225-229.
Z. Yang, J. Xu, Synthesis, 2013, 45, 1675-1682.
Key Words
sulfonyl chlorides, sodium chlorite, oxidative chlorosulfonation, synthetic methods, isothioureas
ID: J60-Y2013