Activating Group Recycling in Action: A Rhodium-Catalyzed Carbothiolation Route to Substituted Isoquinolines
Milan Arambasic, Joel F. Hooper and Michael C. Willis*
*Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K., Email: michael.willischem.ox.ac.uk
M. Arambasic, J. F. Hooper, M. C. Willis, Org. Lett., 2013, 15, 5162-5165.
DOI: 10.1021/ol402650q (free Supporting Information)
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A rhodium(I) catalyst enables practical and efficient carbothiolation reactions of alkynes with ortho-ketone-bearing aryl methyl sulfides. The resulting carbothiolation adducts are convenient precursors to highly substituted isoquinolines.
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