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Activating Group Recycling in Action: A Rhodium-Catalyzed Carbothiolation Route to Substituted Isoquinolines

Milan Arambasic, Joel F. Hooper and Michael C. Willis*

*Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K., Email:

M. Arambasic, J. F. Hooper, M. C. Willis, Org. Lett., 2013, 15, 5162-5165.

DOI: 10.1021/ol402650q (free Supporting Information)

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A rhodium(I) catalyst enables practical and efficient carbothiolation reactions of alkynes with ortho-ketone-bearing aryl methyl sulfides. The resulting carbothiolation adducts are convenient precursors to highly substituted isoquinolines.

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Key Words


ID: J54-Y2013