Efficient Chromium(II)-Catalyzed Cross-Coupling Reactions between Csp² Centers

Andreas K. Steib, Olesya M. Kuzmina, Sarah Fernandez, Dietmar Flubacher and Paul Knochel*

*Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich, Germany, Email: paul.knochelcup.uni-muenchen.de

A. K. Steib, O. M. Kuzmina, S. Fernandez, D. Flubacher, P. Knochel, J. Am. Chem. Soc., 2013, 135, 15346-15349.

DOI: 10.1021/ja409076z

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Abstract

Low-toxicity chromium(II) chloride catalyzes very fast coupling reactions of various (hetero)arylmagnesium reagents with N-heterocyclic halides, aromatic halogenated ketones or imines, and alkenyl iodides at room temperature. Remarkably, much lower amounts of homo-coupling side products are obtained compared to related iron, cobalt, or manganese cross-couplings.

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Key Words

Heterobiaryls, Biaryls, Styrenes

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ID: J48-Y2013