DMAP-Catalyzed Regel-Type Direct C-2 (Hetero)Aroylation of Oxazoles and Thiazoles Derivatives with Acid Chlorides
Pierrik Lassalas, Francis Marsais, Christophe Hoarau*
*Normandie Université, COBRA, UMR 6014 et FR 3038, Université
de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex,
France,
Email: christophe.hoarau
insa-rouen.fr
P. Lassalas, F. Marsais, C. Hoarau, Synlett, 2013, 24, 2233-2240.
DOI: 10.1055/s-0033-1339858
Abstract
A Regel-type transition-metal-free direct C-2 aroylation of (benzo)oxazoles, (benzo)thiazoles and 1,3,4-oxadiazoles with acid chlorides is catalyzed by N,N-dimethyl-4-aminopyridine (DMAP) and affords the corresponding 2-ketoazoles in good yields.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
acylation, azoles (oxazoles, benzoxazoles, thiazoles, benzothiazoles), C-H functionalization, heterocycles, metal-free, regioselectivity
ID: J60-Y2013
