Use of Primary Amines for the Selective N-Alkylation of Anilines by a Reusable Heterogeneous Catalyst
Pasquale Linciano, Marianna Pizzetti, Andrea Porcheddu, Maurizio Taddei*
*Dipartimento di Biotecnologie, Chimica e Farmacia, UniversitÓ degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy, Email: maurizio.taddeiunisi.it
P. Linciano, M. Pizzetti, A. Porcheddu, M. Taddei, Synlett, 2013, 24, 2249-2254.
DOI: 10.1055/s-0033-1339667 (free Supporting Information)
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An easy Pd-mediated oxidation of primary amines to imines followed by aniline addition enables an alkylation of anilines. The process is characterized by a high atom economy as ammonia is the only byproduct. The catalyst could be successfully recycled up to three times.
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