One-Pot Copper-Catalyzed Three-Component Synthesis of Quinoxalines by Condensation and C-N Bond Formation
Hua Yuan, Kangning Li, Yongxin Chen, Yu Wang, Jiaojiao Cui, Baohua Chen*
*Key Laboratory of Nonferrous Metal Chemistry and Resources
Utilization of Gansu Province, Lanzhou 730000, P. R. of China, Email: chbh
lzu.edu.cn
H. Yuan, K. Li, Y. Chen, Y. Wang, J. Cui, B. Chen, Synlett, 2013, 24, 2315-2319.
DOI: 10.1055/s-0033-1339797
Abstract
Copper-catalyzed condensation and C-N bond formation of 2-iodoanilenes, arylacetaldehydes, and sodium azide, in a one-pot three-component reaction enables the synthesis of quinoxalines in good yields. Under optimized reaction conditions, starting materials were reacted in the presence of CuI, K2CO3 in DMSO at 80°C for 20 hours.
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Key Words
quinoxalines, arylacetaldehydes, sodium azide, multicomponent reaction
ID: J60-Y2013
