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Employing Arynes in Transition-Metal-Free Monoarylation of Aromatic Tertiary Amines

Sachin Suresh Bhojgude, Trinadh Kaicharla and Akkattu T. Biju*

*Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune - 411008, India, Email:

S. S. Bhojgude, T. Kaicharla, A. T. Biju, Org. Lett., 2013, 15, 5452-5455.

DOI: 10.1021/ol4029258


The use of arynes enables a transition-metal-free approach to a highly monoselective N-arylation of aromatic tertiary amines. The reaction afforded functionalized diaryl amines in good yield. High levels of functional group compatibility and high yields of products are the notable features of the reaction.

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ID: J54-Y2013