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Iridium-Catalyzed Direct Arene C-H Bond Amidation with Sulfonyl- and Aryl Azides

Donggun Lee, Youngchan Kim and Sukbok Chang*

*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejon 307-701, Republic of Korea, Email:

D. Lee, Y. Kim, S. Chan, J. Org. Chem., 2013, 78, 11102-11109.

DOI: 10.1021/jo4019683

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Iridium-catalyzed direct ortho C-H amidation of arenes works well with sulfonyl- and aryl azides as the nitrogen source. The reaction proceeds efficiently with a broad range of conventional directing groups with excellent functional group compatibility under mild conditions via 5- as well as 6-membered iridacycle intermediates.

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Key Words

sulfonamides, arylation, anilines

ID: J42-Y2013