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Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates

Brett R. Ambler and Ryan A. Altman*

*Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States, Email: raaltmanku.edu

B. R. Ambler, R. A. Altman, Org. Lett., 2013, 15, 5578-5581.

DOI: 10.1021/ol402780k


Abstract

A copper-catalyzed decarboxylation of allylic bromodifluoroacetates enables the conversion of allylic alcohols to trifluoromethanes in two steps. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions.


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Catalytic One-Step Deoxytrifluoromethylation of Alcohols

F. de Azambuja, S. M. Lovrien, P. Ross, B. R. Amber, R. A. Altman, J. Org. Chem., 2019, 84, 2061-2071.


Key Words

trifluoromethylation


ID: J54-Y2013