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Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives

Zhongyan Chen, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Xiaobo Huang and Huayue Wu*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:,

Z. Chen, J. Chen, M. Liu, J. Ding, W. Gao, X. Huang, H. Wu, J. Org. Chem., 2013, 78, 11342-11348.

DOI: 10.1021/jo401908g


An efficient copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride leads to a wide range of 2-substituted quinazolines in good yields. The method tolerates a various functional groups and represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.

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Key Words

Quinazolines, oxygen, TEMPO

ID: J42-Y2013