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Synthesis of 4-Arylquinazolines by Arylation of Quinazolin-4-ones under Mild Conditions

Guanyinsheng Qiu, Ping Huang, Qin Yang, Hui Lu, Jingshi Xu, Zhihong Deng, Ming Zhang, Yiyuan Peng*

*Key Laboratory of Green Chemistry, Jiangxi Province and College of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China, Email:

G. Qiu, P. Huang, Q. Yang, H. Lu, J. Xu, Z. Deng, M. Zhang, Y. Peng, Synthesis, 2013, 45, 3131-3136.

DOI: 10.1055/s-0033-1339848 (free Supporting Information)


An efficient route to 4-arylquinazolines in very good yields is carried out under mild conditions by the palladium-catalyzed arylation of quinazolin-4-ones with arylboronic acids in the presence of TsCl.

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Key Words

quinazolines, arylation, arylboronic acids, quinazolin-4-ones

ID: J66-Y2013