Indium(III)-Catalyzed One-Pot Synthesis of Alkyl Cyanides from Carboxylic Acids
Toshimitsu Moriya, Kohei Shoji, Shinichiro Yoneda, Reiko Ikeda, Takeo Konakahara, Norio Sakai*
*Department of Pure and Applied Chemistry, Faculty of Science
and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510,
Japan, Email: sakachem
rs.noda.tus.ac.jp
T. Moriya, K. Shoji, S. Yoneda, R. Ikeda, T. Konakahara, N. Sakai, Synthesis, 2013, 45, 3233-3238.
DOI: 10.1055/s-0033-1339903
see article for more reactions
Abstract
Indium(III)-catalyzed reductive iodination or bromination of carboxylic acids enables a one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides.
see article for more examples
Indium-Catalyzed Reductive Bromination of Carboxylic Acids Leading to Alkyl Bromides
T. Moriya, S. Yoneda, K. Kawana, R. Ikeda, T. Konakahara, N. Sakai, Org. Lett., 2012, 14, 4842-4845.
Key Words
indium, TMDS, deoxygenation, halogenation, carboxylic acids, nitriles
ID: J66-Y2013
