Organic Chemistry Portal



Indium(III)-Catalyzed One-Pot Synthesis of Alkyl Cyanides from Carboxylic Acids

Toshimitsu Moriya, Kohei Shoji, Shinichiro Yoneda, Reiko Ikeda, Takeo Konakahara, Norio Sakai*

*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan, Email:

T. Moriya, K. Shoji, S. Yoneda, R. Ikeda, T. Konakahara, N. Sakai, Synthesis, 2013, 45, 3233-3238.

DOI: 10.1055/s-0033-1339903

see article for more reactions


Indium(III)-catalyzed reductive iodination or bromination of carboxylic acids enables a one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides.

see article for more examples

Indium-Catalyzed Reductive Bromination of Carboxylic Acids Leading to Alkyl Bromides

T. Moriya, S. Yoneda, K. Kawana, R. Ikeda, T. Konakahara, N. Sakai, Org. Lett., 2012, 14, 4842-4845.

Key Words

indium, TMDS, deoxygenation, halogenation, carboxylic acids, nitriles

ID: J66-Y2013