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Copper-Catalyzed Oxidative Decarboxylative Arylation of Benzothiazoles with Phenylacetic Acids and α-Hydroxyphenylacetic Acids with O2 as the Sole Oxidant

Qiuling Song*, Qiang Feng and Mingxin Zhou

*School of Biomedical Sciences at Huaqiao Univeristy, Xiamen, Fujian, 361021, China, Email:

Q. Song, Q. Feng, M. Zhou, Org. Lett., 2013, 15, 5990-5993.

DOI: 10.1021/ol402871f


A Cu(II)-catalyzed oxidative decarboxylation of phenylacetic acids and α-hydroxyphenylacetic acids enables the synthesis of various 2-aryl benzothiazoles in good yields from 2-unsubstituted benzothiazoles in the presence of oxygen as the sole oxidant. The reaction proceeds via Cu(II)-catalyzed decarboxylation, C-H bond oxidation, ring-opening, and condensation steps in one-pot and tolerates various functional groups.

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Key Words

benzothiazoles, oxygen

ID: J54-Y2013