A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides
Tamara Beisel and Georg Manolikakes *
*Department of Organic Chemistry and Chemical Biology,
Goethe-University Frankfurt, Frankfurt am Main, Germany, Email: g.manolikakes
chemie.uni-frankfurt.de
T. Beisel, G. Manolikakes, Org. Lett., 2013, 15, 6046-6049.
DOI: 10.1021/ol402949t
Abstract
A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids enables a practical and general synthesis of α-substituted amides from simple, readily available building blocks.
see article for more examples
Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines
T. Beisel, G. Manolikakes, Org. Lett., 2015, 17, 3162-3165.
Key Words
benzylic amines, diarylmethylamines, multicomponent reactions
ID: J54-Y2013
