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A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides

Tamara Beisel and Georg Manolikakes *

*Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main, Germany, Email:

T. Beisel, G. Manolikakes, Org. Lett., 2013, 15, 6046-6049.

DOI: 10.1021/ol402949t


A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids enables a practical and general synthesis of α-substituted amides from simple, readily available building blocks.

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Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines

T. Beisel, G. Manolikakes, Org. Lett., 2015, 17, 3162-3165.

Key Words

benzylic amines, diarylmethylamines, multicomponent reactions

ID: J54-Y2013