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One-Pot Synthesis of Nitriles from Aldehydes Catalyzed by Deep Eutectic Solvent

Umakant B. Patil, Suresh S. Shendage, Jayashree M. Nagarkar*

*Department of Chemistry, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai 400 019, India, Email:

U. B. Patil, S. S. Shendage, J. M. Nagarkar, Synthesis, 2013, 45, 3295-3299.

DOI: 10.1055/s-0033-1339904


A deep eutectic mixture of choline chloride and urea (1:2) is an efficient and ecofriendly catalyst for the one-pot synthesis of nitriles from aldehydes under solvent-free conditions under both conventional and microwave irradiation. Nitriles were obtained in good to excellent yields.

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Key Words

nitriles, deep eutectic solvent, aldehydes, hydroxylamine hydrochloride, microwave synthesis, green chemistry

ID: J66-Y2013