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Study on the Influence of a Sustainable Medium for the Design of Multistep Processes: Three-Component Synthesis of 2-Nitroamines

Calogero G. Piscopo, Giovanni Sartori, JosÚ A. Mayoral, Daniela Lanari, Luigi Vaccaro, Raimondo Maggi*

*Clean Synthetic Methodology Group, Dipartimento di Chimica dell'UniversitÓ, Viale G. P. Usberti 17A, 43124 Parma, Italy, Email:

C. G. Piscopo, G. Sartori, J. A. Mayoral, D. Lanari, L. Vaccaro, R. Maggi, Synlett, 2013, 24, 2596-2600.

DOI: 10.1055/s-0033-1339898

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Heating a solution of an aldehyde, an aromatic amine, and a nitroalkane in 20% water-methanol at 60 ░C for five hours enables an environmentally benign three-component, one-pot synthesis of 2-nitroamines in the absence of a catalyst.

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Key Words

coupling, Mannich bases, multicomponent reactions, Schiff bases, solvent effects, nitro compounds, aryl amines

ID: J60-Y2013