Cross-Hetero-Dehydrogenative Coupling Reaction of Phosphites: A Catalytic Metal-Free Phosphorylation of Amines and Alcohols

Jayaraman Dhineshkumar and Kandikere Ramaiah Prabhu*

*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India, Email: prabhuorgchem.iisc.ernet.in

J. Dhineshkumar, K. R. Prabhu, Org. Lett., 2013, 15, 6062-6065.

DOI: 10.1021/ol402956b

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Abstract

Phosphorylation of amines, alcohols, and sulfoximines provides various phosphoramidates, phosphorus triesters and sulfoximine-derived phosphoramidates using molecular iodine as a catalyst and H₂O₂ as the sole oxidant under mild reaction conditions.

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Key Words

phosphoramidates, phosphorus triesters, hydrogen peroxide, iodine

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ID: J54-Y2013