Copper-Catalyzed Domino Synthesis of Quinazolin-4(3H)-ones from (Hetero)arylmethyl Halides, Bromoacetate, and Cinnamyl Bromide
Haidong Wei, Tianbin Li, Yue Zhou, Lihong Zhou, Qingle Zeng*
*Institute of Green Catalysis and Synthesis, College of
Materials and Chemistry & Chemical Engineering, Chengdu University of
Technology, Chengdu 610059, P. R. of China,
Email: qinglezeng
hotmail.com
H. Wei, T. Li, Y. Zhou, L. Zhou, Q. Zeng, Synthesis, 2013, 45, 3349-3354.
DOI: 10.1055/s-0033-1340040
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Abstract
Copper(I) bromide catalyzes a domino reaction of alkyl halides and anthranilamides under air to afford 2-substituted quinazolin-4(3H)-ones in good to excellent yields and with wide functional group tolerance. A mechanism via a four-step domino reaction is proposed.
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Key Words
copper, condensation, tandem reaction, oxygenation, quinazolin-4(3H)-ones, oxygen
ID: J66-Y2013
