Copper-Catalyzed Domino Synthesis of Quinazolin-4(3H)-ones from (Hetero)arylmethyl Halides, Bromoacetate, and Cinnamyl Bromide
Haidong Wei, Tianbin Li, Yue Zhou, Lihong Zhou, Qingle Zeng*
*Institute of Green Catalysis and Synthesis, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P. R. of China, Email: qinglezenghotmail.com
H. Wei, T. Li, Y. Zhou, L. Zhou, Q. Zeng, Synthesis, 2013, 45, 3349-3354.
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Copper(I) bromide catalyzes a domino reaction of alkyl halides and anthranilamides under air to afford 2-substituted quinazolin-4(3H)-ones in good to excellent yields and with wide functional group tolerance. A mechanism via a four-step domino reaction is proposed.
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copper, condensation, tandem reaction, oxygenation, quinazolin-4(3H)-ones, oxygen