Copper-Catalyzed Oxidative Three-Component Synthesis of N,N′,N″-Trisubstituted Guanidines

Jihui Li and Luc Neuville *

*Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, Laboratoire International Associé, CNRS, 91198 Gif-sur-Yvette Cedex, France, Email: luc.neuvillecnrs.fr

J. Li, L. Neuville, Org. Lett., 2013, 15, 6124-6127.

DOI: 10.1021/ol4029622

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Abstract

An operationally simple and rapid copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines is performed in the presence of K₂CO₃, a catalytic amount of CuCl₂·2H₂O, bipyridine, and oxygen (1 atm).

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Key Words

Condensation, N-Functionalization, Oxygen, Multicomponent Reactions

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ID: J54-Y2013