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Nickel-Catalyzed Aromatic C-H Alkylation with Secondary or Tertiary Alkyl-Bromine Bonds for the Construction of Indolones

Chao Liu, Dong Liu, Wei Zhang, Liangliang Zhou and Aiwen Lei*

*College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P. R. China, Email:

C. Liu, D. Liu, W. Zhang, L. Zhou, A. Lei, Org. Lett., 2013, 15, 6166-6169.

DOI: 10.1021/ol403021p


A nickel-catalyzed aromatic C-H alkylation with tertiary or secondary alkyl-Br bonds enables the construction of indolones. The reaction tolerates various functional groups. Moreover, challenging secondary alkyl bromides can also be transformed. Radical trapping and photocatalysis conditions exhibited that a radical process is involved in this aromatic C-H alkylation.

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ID: J54-Y2013