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Synthesis of Heteroaryl Compounds through Cross-Coupling Reaction of Aryl Bromides or Benzyl Halides with Thienyl and Pyridyl Aluminum Reagents

Xu Chen, Lingmin Zhou, Yimei Li, Tao Xie and Shuangliu Zhou*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan, Email:

X. Chen, L. Zhou, Y. Li, T. Xie, S. Zhou, J. Org. Chem., 2014, 79, 230-239.

DOI: 10.1021/jo4024123


Cross-coupling of aryl bromides with 2-thienyl, 3-thienyl, 2-pyridyl, and 3-pyridyl aluminum reagents in the presence of Pd(OAc)2 and (o-tolyl)3P provides useful biaryl building blocks. Additionally, the catalytic system was also suited well for the coupling reaction of benzyl halides with pyridyl aluminum reagents to afford a series of pyridylarylmethanes.

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Key Words

thiophenes, pyridines

ID: J42-Y2014