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DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones

Yang Li, Dong Xue*, Wei Lu, Chao Wang, Zhao-Tie Liu and Jianliang Xiao*

*Shaanxi Normal University, Xi'an 710062, China; University of Liverpool, Liverpool L69 7ZD, United Kingdom, Email:,

Y. Li, D. Xue, W. Lu, C. Wang, Z.-T. Liu, J. Xiao, Org. Lett., 2014, 16, 66-69.

DOI: 10.1021/ol403040g

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An unprecedented Rh-catalyzed direct methylation of ketones with N,N-dimethylformamide shows a broad substrate scope. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride during the methylation process.

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Key Words

α-alkylation, ammonium peroxydisulfate

ID: J54-Y2014