DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones
Yang Li, Dong Xue*, Wei Lu, Chao Wang, Zhao-Tie Liu and Jianliang Xiao*
*Shaanxi Normal University, Xi'an 710062, China; University of Liverpool, Liverpool L69 7ZD, United Kingdom, Email: xuedong_welcomesnnu.edu.cn, j.xiaoliverpool.ac.uk
Y. Li, D. Xue, W. Lu, C. Wang, Z.-T. Liu, J. Xiao, Org. Lett., 2014, 16, 66-69.
DOI: 10.1021/ol403040g (free Supporting Information)
see article for more reactions
An unprecedented Rh-catalyzed direct methylation of ketones with N,N-dimethylformamide shows a broad substrate scope. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride during the methylation process.
see article for more examples