Chemoselective Reductions of Nitroaromatics in Water at Room Temperature
Sean M. Kelly and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu
S. M. Kelly, B. H. Lipshutz, Org. Lett., 2014, 16, 98-101.
DOI: 10.1021/ol403079x (free Supporting Information)
A robust and green protocol for the reduction of functionalized nitroarenes to the corresponding primary amines relies on inexpensive zinc dust in water containing nanomicelles derived from the commercially available designer surfactant TPGS-750-M. This mild process takes place at room temperature and tolerates a wide range of functionalities including common protecting groups.
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N. R. Lee, A. A. Bikovtseva, M. Cortes-Clerget, F. Gallou, B. H. Lipshutz, Org. Lett., 2017, 19, 6518-6521.