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Palladium-Catalyzed α-Arylation of Benzylic Phosphine Oxides

Sonia Montel, Tiezheng Jia and Patrick J. Walsh*

*Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States, Email:

S. Montel, T. Jia, P. J. Walsh, Org. Lett., 2014, 16, 130-133.

DOI: 10.1021/ol403124g (free Supporting Information)


A Pd(OAc)2/Xantphos-based catalyst enabled a deprotonative cross-coupling process between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides to prepare diarylmethyl phosphine oxides in very good yields.

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Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

S. Montel, L. Raffier, Y. He, P. J. Walsh, Org. Lett., 2014, 16, 1446-1449.

Palladium-Catalyzed Direct Arylation of Methyl Sulfoxides with Aryl Halides

T. Jia, A. Bellomo, K. El Baina, S. D. Dreher, P. J. Walsh, J. Am. Chem. Soc., 2013, 135, 3740-3743.

Key Words

α-Arylation, Phosphine Oxides

ID: J54-Y2014