One-Pot Regiospecific Synthesis of Imidazo[1,2-a]pyridines: A Novel, Metal-Free, Three-Component Reaction for the Formation of C-N, C-O, and C-S Bonds

Hua Cao*, Xiaohang Liu, Limin Zhao, Jinghe Cen, Jingxin Lin, Qiuxia Zhu and Minling Fu

*School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. of China, Email: caohuagdpu.edu.cn

H. Cao, X. Liu, L. Zhao, J. Cen, J. Lin, Q. Zhu, M. Fu, Org. Lett., 2014, 16, 146-149.

DOI: 10.1021/ol4031414

---

see article for more reactions

Abstract

A facile formation of C-N, C-O, and C-S bonds from ynals, pyridin-2-amines, and alcohols or thiols enables a transition-metal-free three-component reaction for the construction of imidazo[1,2-a]pyridines.

see article for more examples

---

---

Key Words

Imidazo[1,2-a]pyridines, Multicomponent Reactions

---

ID: J54-Y2014