A Palladium-Catalyzed Regioselective Hydroesterification of Alkenylphenols to Lactones with Phenyl Formate as CO Source
Haining Wang, Ben Dong, Yang Wang, Jingfu Li and Yian Shi*
*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email: yianlamar.colostate.edu
H. Wang, B. Dong, Y. Wang, J. Li, Y. Shi, Org. Lett., 2014, 16, 186-189.
DOI: 10.1021/ol403171p (free Supporting Information)
see article for more reactions
An effective Pd-catalyzed hydroesterification of alkenylphenols with phenyl formate as CO surrogate enables the synthesis of various lactones in generally high yields with high regioselectivities. In one case, 76% ee is obtained with a chiral ligand.
see article for more examples