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A Palladium-Catalyzed Regioselective Hydroesterification of Alkenylphenols to Lactones with Phenyl Formate as CO Source

Haining Wang, Ben Dong, Yang Wang, Jingfu Li and Yian Shi*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email: yianlamar.colostate.edu

H. Wang, B. Dong, Y. Wang, J. Li, Y. Shi, Org. Lett., 2014, 16, 186-189.

DOI: 10.1021/ol403171p (free Supporting Information)



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Abstract

An effective Pd-catalyzed hydroesterification of alkenylphenols with phenyl formate as CO surrogate enables the synthesis of various lactones in generally high yields with high regioselectivities. In one case, 76% ee is obtained with a chiral ligand.

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Key Words

lactones, benzofuranones


ID: J54-Y2014