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4-(N,N-Dimethylamino)pyridine Hydrochloride as a Recyclable Catalyst for Acylation of Inert Alcohols: Substrate Scope and Reaction Mechanism

Zhihui Liu, Qiaoqiao Ma, Yuxiu Liu and Qingmin Wang*

*State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China, Email:

Z. Liu, Y. Liu, Q. Wang, Org. Lett., 2014, 16, 236-239.

DOI: 10.1021/ol4030875


4-(N,N-Dimethylamino)pyridine hydrochloride (DMAP·HCl) was used as a recyclable catalyst for the acylation of inert alcohols and phenols under base-free conditions. The catalyst can be reused more than eight times without loss in activity and works with various acylating reagents.

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Key Words

acylation, acetates, pivalates, benzoates

ID: J54-Y2014