A Simple Method for the Electrophilic Cyanation of Secondary Amines
Chen Zhu, Ji-Bao Xia and Chuo Chen*
*University of Texas Southwestern Medical Center, Department
of Biochemistry, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States, Email:
Chuo.Chen
UTSouthwestern.edu
C. Zhu, J.-B. Xia, C. Chen, Org. Lett., 2014, 16, 247-249.
DOI: 10.1021/ol403245r
Abstract
Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction enables the synthesis of disubstituted cyanamides without using highly toxic cyanogen halides.
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Key Words
ID: J54-Y2014
