Copper-Catalyzed Intermolecular Cyanotrifluoromethylation of Alkenes
Yu-Tao He, Lian-Hua Li, Yan-Fang Yang, Zhao-Zhao Zhou, Hui-Liang Hua, Xue-Yuan Liu and Yong-Min Liang*
*State Key Laboratory of Applied Organic Chemistry, Lanzhou
University, Lanzhou 730000, P.R. China, Email:
liangym
lzu.edu.cn
Y.-T. He, L.-H. Li, Y.-F. Yang, Z.-Z. Zhou, H.-L. Hua, X.-Y. Liu, Y.-M. Liang, Org. Lett., 2014, 16, 270-273.
DOI: 10.1021/ol403263c
Abstract
A highly practical copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes provides a general and straightforward way to synthesize various useful CF3-containing nitriles, which can be used for the preparation of pharmaceutically and agrochemically important compounds.
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Key Words
cyanation, trifluoromethylation, multicomponent reactions
ID: J54-Y2014
