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Synergistic Au/Ga Catalysis in Ambient Nakamura Reaction

Yumeng Xi, Dawei Wang, Xiaohan Ye, Novruz G. Akhmedov, Jeffrey L. Petersen and Xiaodong Shi*

*C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States, Email: xmshiusf.edu

Y. Xi, D. Wang, X. Ye, N. G. Akhmedov, J. L. Petersen, X. Shi, Org. Lett., 2014, 16, 306-309.

DOI: 10.1021/ol403337u (free Supporting Information)


Abstract

A synergistic gold/gallium catalysis enables an intermolecular addition of 1,3-dicarbonyl compounds to unactivated 1-alkynes (Nakamura reaction) at room temperature. The developed system is highly efficient with a very low gold catalyst loading.

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Key Words

Nakamura reaction, active methylenes


ID: J54-Y2014