Copper-Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Acetonitrile to β-Ketonitriles
Jiaxuan Shen, Dejun Yang, Yuxiao Liu, Shuangshuang Qin, Jingwu Zhang, Jiangkai Sun, Chunhui Liu, Chaoyang Liu, Xiaomei Zhao, Changhu Chu and Renhua Liu*
*School of Pharmacy, East China University of Science and
Technology, Meilong Road 130, Shanghai 200237, China, Email: liurh
ecust.edu.cn
J. Shen, D. Yang, Y. Liu, S. Qin, J. Zhang, J. Sun, C. Liu, C. Liu, X. Zhao, C. Chu, R. Liu, Org. Lett., 2014, 16, 350-353.
DOI: 10.1021/ol403555n
Abstract
A green, practical, convenient, and cheap copper-catalyzed oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles involves a C-C coupling with loss of two hydrogen atoms from the corresponding two carbons, using oxygen as the terminal oxidant.
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Key Words
Acylation, Cyanomethylation, Oxydation, Oxygen
ID: J54-Y2014
