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Copper-Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Acetonitrile to β-Ketonitriles

Jiaxuan Shen, Dejun Yang, Yuxiao Liu, Shuangshuang Qin, Jingwu Zhang, Jiangkai Sun, Chunhui Liu, Chaoyang Liu, Xiaomei Zhao, Changhu Chu and Renhua Liu*

*School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China, Email:

J. Shen, D. Yang, Y. Liu, S. Qin, J. Zhang, J. Sun, C. Liu, C. Liu, X. Zhao, C. Chu, R. Liu, Org. Lett., 2014, 16, 350-353.

DOI: 10.1021/ol403555n (free Supporting Information)


A green, practical, convenient, and cheap copper-catalyzed oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles involves a C-C coupling with loss of two hydrogen atoms from the corresponding two carbons, using oxygen as the terminal oxidant.

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Key Words

Acylation, Cyanomethylation, Oxydation, Oxygen

ID: J54-Y2014