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Solvent-Free, Base-Free Microwave-Mediated Iridium-Catalyzed N-Alkylation of Amides with Alcohols

Tushar D. Apsunde, Mark L. Trudell*

*Department of Chemistry, University of New Orleans, New Orleans, LA 70148, Email: mtrudelluno.edu

T. D. Apsunde, M. L. Trudell, Synthesis, 2014, 46, 230-234.

DOI: 10.1055/s-0033-1340142 (free Supporting Information)


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Abstract

Solvent-free, base-free microwave-mediated (Cp*IrCl2)2-catalyzed conditions for the N-alkylation of amides with a series of primary and secondary alcohols produce high yields of N-alkyl arylamides and N-alkyl alkylamides.

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Key Words

alcohols, alkylation of amides, iridium, microwave synthesis


ID: J66-Y2014