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Iron-Catalyzed Reductive Cyclization of 1,6-Enynes

Aijun Lin, Zhi-Wei Zhang and Jiong Yang*

*Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255, United States, Email:

A. Lin, Z.-W. Zhang, J. Yang, Org. Lett., 2014, 16, 386-389.

DOI: 10.1021/ol403257x


FeCl2 and an iminopyridine ligand form in the presence of diethylzinc and magnesium bromide etherate an active catalyst for the reductive cyclization of N- and O-tethered 1,6-enynes to give pyrrolidine and tetrahydrofuran derivatives.

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Key Words

Pyrrolidines, Tetrahydrofurans

ID: J54-Y2014