Catalyst-Controlled Wacker-Type Oxidation: Facile Access to Functionalized Aldehydes
Zachary K. Wickens, Kacper Skakuj, Bill Morandi and Robert H. Grubbs*
*Division of Chemistry and Chemical Engineering, California
Institute of Technology, Pasadena, California 91125, United States, Email: rhg
caltech.edu
Z. K. Wickens, K. Skakuj, B. Morandi, R. H. Grubbs, J. Am. Chem. Soc., 2014, 136, 890-893.
DOI: 10.1021/ja411749k
Abstract
An aldehyde-selective oxidation of alkenes bearing diverse oxygen groups in the allylic and homoallylic position was accomplished with a nitrite-modified Wacker oxidation. Readily available oxygenated alkenes were selectively oxidized to aldehydes in good yield.
see article for more examples
Efficient and Highly Aldehyde Selective Wacker Oxidation
P. Teo, Z. K. Wickens, G. Dong, R. H. Grubbs, Org. Lett., 2012, 14, 3237-3239.
Key Words
ID: J48-Y2014
