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Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles from N-Alkylated Tosylhydrazones and Terminal Alkynes

Yuanfang Kong, Meng Tang* and Yun Wang

*School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China, Email: tangmenglzu.edu.cn

Y. Kong, M. Tang, Y. Wang, Org. Lett., 2014, 16, 576-579.

DOI: 10.1021/ol403447g (free Supporting Information)


Abstract

An efficient synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes converted a wide range of substrates. In comparison with common syntheses of substituted pyrazoles, this methodology offers complete regioselectivity, especially, if similar substituents are present.

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Key Words

pyrazoles


ID: J54-Y2014