Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles from N-Alkylated Tosylhydrazones and Terminal Alkynes
Yuanfang Kong, Meng Tang* and Yun Wang
*School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China, Email: tangmenglzu.edu.cn
Y. Kong, M. Tang, Y. Wang, Org. Lett., 2014, 16, 576-579.
DOI: 10.1021/ol403447g (free Supporting Information)
An efficient synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes converted a wide range of substrates. In comparison with common syntheses of substituted pyrazoles, this methodology offers complete regioselectivity, especially, if similar substituents are present.
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