Organic Chemistry Portal



Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles from N-Alkylated Tosylhydrazones and Terminal Alkynes

Yuanfang Kong, Meng Tang* and Yun Wang

*School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China, Email:

Y. Kong, M. Tang, Y. Wang, Org. Lett., 2014, 16, 576-579.

DOI: 10.1021/ol403447g


An efficient synthesis of 1,3,5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and terminal alkynes converted a wide range of substrates. In comparison with common syntheses of substituted pyrazoles, this methodology offers complete regioselectivity, especially, if similar substituents are present.

see article for more examples

Key Words


ID: J54-Y2014