Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides
Jianfei Bai, Bartosz K. Zambroń and Pierre Vogel*
*Laboratoire de Glycochimie et de Synthèse Asymétrique, Swiss
Federal Institute of Technology (EPFL), Batochime, CH 1015 Lausanne, Switzerland, Email:
Pierre.Vogel
epfl.ch
J. Bai, B. K. Zembrón, P. Vogel, Org. Lett., 2014, 16, 604-607.
DOI: 10.1021/ol403508j
Abstract
The use of sulfinylamides generated in situ by the reaction of pure amines with prop-2-ene-1-sulfinyl chloride enables an efficient amidification of carboxylic acids. The method allows the conversion of aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines and tolerates acids bearing unprotected alcohol, phenol, and ketone moieties without α-epimerization.
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Key Words
ID: J54-Y2014
