Organic Chemistry Portal



Synthesis of 2-Aminoquinoxalines via One-Pot Cyanide-Based Sequential Reaction under Aerobic Oxidation Conditions

Yeon-Ho Cho, Kyung-Hee Kim and Cheol-Hong Cheon*

*Department of Chemistry, Korea University, Anam-ro, Seongbuk-gu, Seoul 136701, Republic of Korea, India, Email:

Y.-H. Cho, K.-H. Kim, C.-H. Cheon, J. Org. Chem., 2014, 79, 901-907.

DOI: 10.1021/jo4021908


One-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions afford 2-aminoquinoxalines in high yields. Various substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable.

see article for more examples

Key Words

quinoxalines, oxygen

ID: J42-Y2014