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Benzoquinone-Promoted Aerobic Oxidative Hydroxylation of Arylboronic Acids in Water

Guolin Cheng, Xiaobao Zeng, Xiuling Cui*

*Institute of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. of China, Email:

G. Chen, X. Zeng, X. Cui, Synthesis, 2014, 46, 263-268.

DOI: 10.1055/s-0033-1338571


A general and efficient aerobic oxidative hydroxylation of arylboronic acids promoted by benzoquinone provides phenols in very good yields. The main advantages of this protocol are the use of water as solvent in the presence of a catalytic amount of benzoquinone under metal-free conditions.

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Key Words

benzoquinone, arylboronic acids, oxidation, oxygen, phenols

ID: J66-Y2014