One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

Teng Niu, Ke-Hu Wang, Danfeng Huang*, Changming Xu, Yingpeng Su, Yulai Hu*, Ying Fu

*College of Chemistry and Chemical Engineering, Northwest Normal University, Anning Road 967 (E), Lanzhou 730070, P. R. of China, Email: huangdfnwnu.edu.cn, huylnwnu.edu.cn

T. Niu, K.-H. Wang, D. Huang, C. Xu, Y, Su, Y. Hu, Y. Fu, Synthesis, 2014, 46, 320-330.

DOI: 10.1055/s-0033-1340317

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Abstract

Weinreb amides can be prepared directly from carboxylic acids and N,O-dimethylhydroxylamine in the presence of phosphorus trichloride at 60°C in toluene without separation of the moisture and air sensitive intermediate P[NMe(OMe)]₃. Various functional groups are tolerated and even sterically hindered carboxylic acids give the corresponding Weinreb amides in excellent yields. The method is suitable for large-scale production.

see article for more examples

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A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

T. Niu, W. Zhang, D. Huang, C. Xu, H. Wang, Y. Hu, Org. Lett., 2009, 11, 4474-4477.

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Key Words

Weinreb amides, carboxylic acids, one-pot reaction, coupling, synthesis

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ID: J66-Y2014