Organic Chemistry Portal



Decarboxylative Trichloromethylation of Aromatic Aldehydes and Its Applications in Continuous Flow

Andreas B. Jensen and Anders T. Lindhardt*

*Department of Engineering, Aarhus University, Finlandsgade 22, 8200 Aarhus N, Denmark, Email:

A. B. Jensen, A. T. Lindhardt, J. Org. Chem., 2014, 79, 1174-1183.

DOI: 10.1021/jo402595r

see article for more reactions


In a synthesis of 2,2,2-trichloromethylcarbinols, a combination of sodium trichloroacetate in the presence of malonic acid enables an efficient transformation of electron deficient aldehydes in DMSO, whereas electron-rich aldehydes did not require the addition of malonic acid. By performing this decarboxylative reaction in continuous flow, scale-up of the reaction could be achieved with a simple and safe setup.

see article for more examples

see article for more examples

Key Words

2,2,2-trichloromethylcarbinols, flow chemistry

ID: J42-Y2014