Decarboxylative Trichloromethylation of Aromatic Aldehydes and Its Applications in Continuous Flow
Andreas B. Jensen and Anders T. Lindhardt*
*Department of Engineering, Aarhus University, Finlandsgade
22, 8200 Aarhus N, Denmark, Email: lindhardt
chem.au.dk
A. B. Jensen, A. T. Lindhardt, J. Org. Chem., 2014, 79, 1174-1183.
DOI: 10.1021/jo402595r
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Abstract
In a synthesis of 2,2,2-trichloromethylcarbinols, a combination of sodium trichloroacetate in the presence of malonic acid enables an efficient transformation of electron deficient aldehydes in DMSO, whereas electron-rich aldehydes did not require the addition of malonic acid. By performing this decarboxylative reaction in continuous flow, scale-up of the reaction could be achieved with a simple and safe setup.
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Key Words
2,2,2-trichloromethylcarbinols, flow chemistry
ID: J42-Y2014
