Mild and Efficient One-Pot Synthesis of Diverse Flavanone Derivatives via an Organocatalyzed Mannich-Type Reaction
Srinivasu V. N. Vuppalapati, Likai Xia, Naushad Edayadulla, Yong Rok Lee*
*School of Chemical Engineering, Yeungnam University,
Gyeongsan 712-749, South Korea, Email: yrlee
yu.ac.kr
S. V. N. Vuppalapati, L. Xia, N. Edayadulla, Y. R. Lee, Synthesis, 2014, 46, 465-474.
DOI: 10.1055/s-0033-1340466
Abstract
A facile ethylenediamine diacetate (EDDA)-catalyzed one-pot reaction of 2-hydroxyacetophenones, aromatic aldehydes, and aniline provides a rapid access to biologically interesting flavanone derivatives via a Mannich-type reaction. To demonstrate this method, several biologically interesting natural products bearing a flavanone moiety were synthesized.
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Key Words
chromanones, aldehydes, ketones, Mannich bases, Michael addition, cycloaddition
ID: J66-Y2014
