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In Situ Generation of Palladium Nanoparticles: Ligand-Free Palladium Catalyzed Pivalic Acid Assisted Carbonylative Suzuki Reactions at Ambient Conditions

Qing Zhou, Shaohua Wei and Wei Han*

*School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road No. 1, Nanjing 210023, China, Email: whhanweigmail.com

Q. Zhou, S. Wei, W. Han, J. Org. Chem., 2014, 79, 1454-1460.

DOI: 10.1021/jo402366p (free Supporting Information)


Abstract

Highly selective carbonylative Suzuki reactions of aryl iodides with arylboronic acids using an in situ generated nanopalladium system under ambient conditions and in the absence of an added ligand furnished products in high yields. The addition of pivalic acid can effectively suppress an undesired Suzuki coupling. The synthesis can be easily scaled up, and the catalytic system can be reused up to nine times.

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Key Words

aryl ketones


ID: J42-Y2014