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Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

Claudio Battilocchio, Joel M. Hawkins and Steven V. Ley*

*Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, U.K., Email:

C. Battilocchio, J. M. Hawkins, S. V. Ley, Org. Lett., 2014, 16, 1060-1063.

DOI: 10.1021/ol403591c


In a sustainable, robust, reliable, and scalable flow chemistry process for the hydration of nitriles, an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide. A broad range of products are obtained simply by concentration of the output stream without any other workup steps. The protocol shows a high level of chemical tolerance.

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Key Words

hydration, flow chemistry

ID: J54-Y2014