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Ligand-Free Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides and Vinyl Halides

Wan-Ting Tsai, Yun-Yung Lin, Yi-An Chen, Chin-Fa Lee*

*Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, R. O. C., Email: cfaleedragon.nchu.edu.tw

W.-T. Tsai, Y.-Y. Lin, Y.-A. Chen, C.-F. Lee, Synlett, 2014, 25, 443-447.

DOI: 10.1055/s-0033-1340461 (free Supporting Information)



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Abstract

A Cu2O-catalyzed cross-coupling reaction of alkynes with aryl iodides tolerates a broad range of functional groups and enables even the conversion of sterically demanding substrates with only 5-10 mol% of the catalyst.

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Key Words

copper, cross-coupling, ligand-free, aryl iodide, vinyl halide


ID: J60-Y2014