Synthesis of 3,4,5-Trisubstituted Isoxazoles by the 1,3-Dipolar Cycloaddition Reaction of α-Azido Acrylates and Aromatic Oximes
Manman Hu, Xinwei He, Zhiqiang Niu, Zhenglei Yan, Fuyin Zhou, Yongjia Shang*
*Anhui Key Laboratory of Molecule-Based Materials, College of
Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. of
China, Email: shyj
mail.ahnu.edu.cn
M. Hu, X. He, Z. Niu, Z. Yan, F. Zhou, Y. Shang, Synthesis, 2014, 46, 510-514.
DOI: 10.1055/s-0033-1340470
Abstract
A one-pot, cascade reaction sequence of α-azido acrylates and aromatic oximes provides an efficient, straightforward and metal-free synthesis of 3,4,5-trisubstituted isoxazoles under mild reaction conditions via a 1,3-dipolar cycloaddition.
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Key Words
1,3-dipolar cycloaddition, α-azido acrylates, aromatic oximes, isoxazoles, one-pot synthesis, NCS
ID: J66-Y2014
